About one in 10 pregnant women with confirmed Zika infections had a fetus or baby with birth defects, offering the clearest picture yet of the risk of Zika infection during pregnancy, U.S. researchers said on Tuesday.

The report from the Centers for Disease Control and Prevention is the first to analyze a group of U.S. women with clear, confirmed test results of Zika infection during pregnancy.

Once considered a mild disease, a large outbreak of the virus that began in Brazil in 2015 and quickly spread through the Americas revealed that the mosquito-borne virus can cause severe brain damage and microcephaly, or small head size, when women are exposed during pregnancy.

‘Continues to be a threat’

“Zika continues to be a threat to pregnant women across the U.S.,” Dr. Anne Schuchat, acting director of the CDC, said in a statement. “With warm weather and a new mosquito season approaching, prevention is crucial to protect the health of mothers and babies.”

Babies affected by Zika can develop congenital Zika syndrome, which includes brain abnormalities, vision problems, hearing loss, and problems moving limbs.

The study comes from the CDC’s Zika pregnancy registry, which includes data from the continental United States and all U.S. territories except Puerto Rico.

The researchers analyzed data on nearly 1,000 completed pregnancies in 2016 among women who had some evidence of Zika infection. Most were infected through travel to a region where the virus was actively spreading.

Of the 1,000, 51 or about 5 percent had babies or a fetus with one or more Zika-related birth defect. Because of limitations of testing, only tests done within the first few weeks of Zika can test specifically for the Zika virus.

Women analyzed

The team also analyzed 250 women with definitive test results for Zika.

Among these, about one in 10 had a fetus or baby with birth defects. The risk was even higher among women infected in the first trimester of pregnancy, where 15 percent of pregnancies resulted in a fetus or baby with birth defects.

The study also showed that three out of four babies exposed to Zika had not received brain imaging after birth to diagnose birth defects.

“We know that some babies have underlying brain defects that are otherwise not evident at birth. Because we do not have brain imaging reports for most of the infants, our current data might significantly underestimate the impact of Zika,” CDC’s Peggy Honein told a news briefing.

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